Tuesday 2 February 2021

I-Y33765 draft tree January 14th 2021

The style of our latest I-Y33765 phylogenetic tree has changed from that used in previous drafts.  The intention is that this new format should make it easy to see some useful characteristics of the genetic markers directly from the chart.  

For example the names of single nucleotide polymorphism (SNP) markers are now shown in either red or green; those in red are located within the CombBed (non-recombining) regions of the Y-chromosome and consequently we can have high confidence that these SNPs are true mutations suitable for use in age estimations.  On the other hand SNP names shown in green or purple are in less stable areas of the Y-chromosome and may consequently be less reliable and possibly false positives.  Using the high confidence SNPs to calculate the time to most recent common ancestor (TMRCA) for a particular mutation, we can total the number of red SNPs shown on each downstream branch and multiply that number by the clade-specific mutation rate as estimated using the Swensson pedigree (see post January 2021). 

In a similar way the genetic distance (GD) between individuals who have each taken an 111marker short tandem repeat (STR) test can be found directly from the chart.  On the branches of the chart ellipse symbols contain the GD applicable to each particular branch and so it is possible to quickly work out the distance between men who have tested 111STR by adding these GD numbers along the branches that join them. The small version of the chart is annotated with three examples to illustrate this approach.  Hallberg YF80422 is GD17 from Clement IN82043 at 111STR (GD symbols linked by purple line), while he is GD7 from Eklund IN78036 (GD symbols linked by orange line).  The final example (GD symbols linked by pink line) illustrates the GD5 relationship between Clement 236748 and Clement IN82043.

The orange dash symbols on a portion of the Swedish arm of the chart, linking Jacobsson IN70815 and Hallberg YF80422, shows the position of the 19 generation Swensson pedigree used to calculate our clade-specific SNP mutation rate. 

Click on charts to enlarge




1 comment:

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